Bessesen A, Smith-Kielland A, Gadeholt G, Mørland J
Acta Pharmacol Toxicol (Copenh). 1984 Apr;54(4):241-6. doi: 10.1111/j.1600-0773.1984.tb01924.x.
The effect of diethyl ether anaesthesia on in vivo hepatic protein synthetic rates was tested in male Wistar rats. Protein synthesis was measured by an isotope technique after correction for measured levels of precursor specific radioactivity. It was shown that usual anaesthetic levels of diethyl ether reduced the rate of synthesis of liver proteins with 20% compared to a group receiving no anaesthesia. The synthesis/secretion of plasma proteins was much more inhibited, with approximately 70-80%, compared to animals either receiving no anaesthesia or pentobarbital. Monitoring of ether concentrations therefore seems necessary in experiments in which the hepatic capacity for protein synthesis/secretion is measured.
在雄性Wistar大鼠中测试了乙醚麻醉对体内肝脏蛋白质合成速率的影响。在用测量的前体比放射性水平进行校正后，通过同位素技术测量蛋白质合成。结果表明，与未接受麻醉的组相比，常用麻醉水平的乙醚使肝脏蛋白质的合成速率降低了20%。与未接受麻醉或戊巴比妥的动物相比，血浆蛋白质的合成/分泌受到的抑制要大得多，约为70-80%。因此，在测量肝脏蛋白质合成/分泌能力的实验中，监测乙醚浓度似乎是必要的。
