Tuomisto L, Eriksson L, Fyhrquist F
Agents Actions. 1984 Apr;14(3-4):558-60. doi: 10.1007/BF01973871.
Histamine H1-agonists 2-pyridylethylamine (2-PEA) and 2-methylhistamine and H2-agonists 4-methylhistamine, dimaprit and impromidine were given i.c.v. to conscious goats and the release of arginine vasopressin (AVP) was measured. 2-PEA at very low doses (9 and 27 mumoles/animal, equivalent to H1-activity of about 0.5 and 1.5 mumoles histamine, resp.) significantly increased plasma AVP. The H2-agonists did not cause consistent changes in AVP even if their relative doses were higher. It is concluded that the vasopressin releasing effect of histamine is due to H1-receptor activation.
给清醒的山羊脑室内注射组胺H1激动剂2-吡啶乙胺（2-PEA）和2-甲基组胺以及H2激动剂4-甲基组胺、二甲双胍和英普咪定，并测量精氨酸加压素（AVP）的释放。极低剂量的2-PEA（9和27微摩尔/动物，分别相当于约0.5和1.5微摩尔组胺的H1活性）显著增加血浆AVP。即使H2激动剂的相对剂量较高，也不会引起AVP的持续变化。得出结论，组胺的加压素释放作用是由于H1受体激活。
