Marx C M, Alpert S E
Am J Dis Child. 1984 Jul;138(7):670-2. doi: 10.1001/archpedi.1984.02140450052016.
Two children had dysuria, sterile pyuria, and microscopic hematuria develop during treatment with ticarcillin disodium. With the exception of a predominance of pyuria over hematuria, the clinical course and laboratory findings in this disorder were similar to those observed in hemorrhagic cystitis, a potential complication of the use of several semisynthetic penicillins and penicillin G potassium. One patient had urinary abnormalities develop during two courses of ticarcillin therapy and subsequently after initiation of piperacillin sodium therapy. A second patient in whom hemorrhagic cystitis due to carbenicillin disodium developed experienced this related disorder four years later when first exposed to ticarcillin. Neither reduction of the dose nor substitution of one semisynthetic penicillin for another (piperacillin for ticarcillin, ticarcillin for carbenicillin) prevented recurrence of the disorder. The clinical importance of either form of cystitis induced by semisynthetic penicillins is uncertain, as is the risk for progression to interstitial nephritis.
两名儿童在使用替卡西林二钠治疗期间出现排尿困难、无菌性脓尿和镜下血尿。除脓尿比血尿更为突出外，该病症的临床病程和实验室检查结果与出血性膀胱炎相似，出血性膀胱炎是使用几种半合成青霉素和青霉素G钾可能出现的并发症。一名患者在两个疗程的替卡西林治疗期间以及随后开始使用哌拉西林钠治疗后出现了泌尿系统异常。第二名因羧苄西林二钠导致出血性膀胱炎的患者在首次接触替卡西林四年后出现了这种相关病症。减少剂量或用一种半合成青霉素替代另一种（用哌拉西林替代替卡西林，用替卡西林替代羧苄西林）均未能防止该病症复发。半合成青霉素诱发的任何一种膀胱炎的临床重要性尚不确定，进展为间质性肾炎的风险也不确定。
