Am J Epidemiol. 1984 Jun;119(6):931-43.
The third phase of the Lipid Research Clinics North American Population Studies is the Collaborative Family Study (1975-1978), designed to contribute knowledge of the familial association of dyslipoproteinemia and distribution of lipids and lipoproteins among family members. The 2,405 probands of the study were composed of a random (40%) and a hyperlipidemic (60%) component. A total of 15,693 living relatives of these probands were identified, of whom about 75% participated in the study. Demographic, medical, and medication history and lipid and lipoprotein data were collected with strict adherence to a common protocol and standardized laboratory methodology. This report presents the design and scope of the Family Study and the distribution of probands and relatives by clinic, age, selection scheme, and family structure. The possible avenues of analysis and the potential usefulness of this large, high quality data base in assessing the familial determinants of lipid and lipoprotein levels are discussed.
脂质研究临床北美人群研究的第三阶段是协作家庭研究（1975 - 1978年），旨在增进对血脂蛋白异常的家族关联以及家庭成员中脂质和脂蛋白分布的了解。该研究的2405名先证者由随机（40%）和高脂血症（60%）两部分组成。共确定了这些先证者的15693名在世亲属，其中约75%参与了研究。严格按照通用方案和标准化实验室方法收集了人口统计学、医学和用药史以及脂质和脂蛋白数据。本报告介绍了家庭研究的设计和范围，以及按诊所、年龄、选择方案和家庭结构划分的先证者和亲属分布情况。还讨论了可能的分析途径以及这个大型高质量数据库在评估脂质和脂蛋白水平的家族决定因素方面的潜在用途。
