Rowley P T, Lipkin M, Fisher L
Am J Hum Genet. 1984 May;36(3):677-89.
We have assessed the effects of screening and genetic counseling for beta-thalassemia trait on knowledge, attitudes, and behavior in a prospective, controlled study of randomly selected adult members of a health maintenance organization. We report here that knowledge of manifestations and of inheritance of thalassemia, previously reported to be high immediately after counseling, were well maintained at 2 and 10 months following counseling. There was no detectable impairment of self-concept. Marital adjustment improved, and sexual activity increased significantly. Mood, assessed immediately before and after counseling, showed no undesirable changes. A patient-structured counseling method, designed to minimize negative psychological effects via discussion of feelings, was not superior to conventional and programmed methods, described in our previous reports, in terms of learning or attitude change.
在一项对健康维护组织中随机挑选的成年成员进行的前瞻性对照研究中，我们评估了β地中海贫血特征的筛查和遗传咨询对知识、态度和行为的影响。我们在此报告，地中海贫血表现和遗传方面的知识，此前报道在咨询后即刻水平较高，在咨询后2个月和10个月时仍得到良好维持。自我概念未发现有可察觉的损害。婚姻调适得到改善，性活动显著增加。咨询前后即刻评估的情绪未显示出不良变化。一种旨在通过讨论感受将负面心理影响降至最低的患者结构化咨询方法，在学习或态度改变方面并不优于我们之前报告中描述的传统方法和程序化方法。
