Hertz R H, King K C, Kalhan S C
Am J Obstet Gynecol. 1984 Jun 1;149(3):256-60. doi: 10.1016/0002-9378(84)90224-2.
Six women with juvenile-onset diabetes were managed as outpatients during the third trimester of pregnancy with continuous subcutaneous insulin infusion therapy. Twenty-four-hour metabolic profiles for plasma glucose, beta-hydroxybutyrate, and triglycerides were monitored prior to, 1 week, 5 weeks, and 10 weeks after initiation of continuous subcutaneous insulin infusion therapy and compared with the metabolic profiles of 10 normal (nondiabetic) pregnant women. Near-normal metabolic profiles were achieved in these patients after 5 weeks of therapy in this pilot study. Patient motivation, compliance, and understanding of their illness were crucial in achieving the therapeutic goals of normoglycemia.
六名患有青少年期发病糖尿病的女性在妊娠晚期作为门诊患者接受持续皮下胰岛素输注治疗。在开始持续皮下胰岛素输注治疗前、治疗后1周、5周和10周监测血浆葡萄糖、β-羟基丁酸和甘油三酯的24小时代谢谱，并与10名正常（非糖尿病）孕妇的代谢谱进行比较。在这项初步研究中，这些患者在治疗5周后实现了接近正常的代谢谱。患者的积极性、依从性以及对自身疾病的理解对于实现血糖正常的治疗目标至关重要。
