Foss M C, Aoki T T
Department of Medicine, School of Medicine of Ribeirao Preto, Brazil.
Diabetes Care. 1993 Jan;16(1):103-9. doi: 10.2337/diacare.16.1.103.
To characterize the effects of subcutaneous insulin pump therapy on the metabolic response (CHO and lipid oxidation, and nonoxidative glucose metabolism) to a glucose challenge of diabetic women at early pregnancy.
Seven nondiabetic and seven IDDM pregnant patients on insulin pump therapy were studied at the first trimester. Fuel oxidation rates were determined by indirect calorimetry, and blood levels of substrates and hormones were measured before and for 2 h after ingestion of a 50 g oral glucose load.
The increments in npRQ and CHO oxidation rates after the glucose meals in the diabetic women on insulin pump therapy were similar to those in the normal subjects. The glucose disposal data during the 2 h of the studies revealed that the amounts of oxidative and nonoxidative glucose utilization in the control subjects and in the IDDM patients on insulin pump therapy did not show significant differences.
This investigation demonstrated that the treatment of IDDM patients during early pregnancy by an open-loop insulin infusion system is sufficient to normalize their glucose-processing capability with respect to cellular oxidative and nonoxidative glucose metabolism in response to an oral glucose challenge, but some abnormalities in their blood profiles of glucose, lactate, and pyruvate persisted.
探讨皮下胰岛素泵治疗对妊娠早期糖尿病女性葡萄糖耐量试验中代谢反应（碳水化合物和脂质氧化以及非氧化葡萄糖代谢）的影响。
选取7例非糖尿病孕妇和7例接受胰岛素泵治疗的胰岛素依赖型糖尿病（IDDM）孕妇，于孕早期进行研究。通过间接测热法测定燃料氧化率，并在摄入50 g口服葡萄糖负荷前后及之后2小时测量底物和激素的血药浓度。
接受胰岛素泵治疗的糖尿病女性在进糖餐后，非蛋白呼吸商（npRQ）和碳水化合物氧化率的增加与正常受试者相似。研究2小时期间的葡萄糖处置数据显示，对照组受试者和接受胰岛素泵治疗的IDDM患者的氧化和非氧化葡萄糖利用量无显著差异。
本研究表明，在妊娠早期，采用开环胰岛素输注系统治疗IDDM患者足以使其在口服葡萄糖耐量试验中细胞氧化和非氧化葡萄糖代谢方面的葡萄糖处理能力恢复正常，但血糖、乳酸和丙酮酸的血液指标仍存在一些异常。
