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肝硬化肝脏对常温缺血的耐受性。15例患者的临床研究。

Tolerance of the cirrhotic liver to normothermic ischemia. A clinical study of 15 patients.

作者信息

Nagasue N, Yukaya H, Suehiro S, Ogawa Y

出版信息

Am J Surg. 1984 Jun;147(6):772-5. doi: 10.1016/0002-9610(84)90198-3.

DOI:10.1016/0002-9610(84)90198-3
PMID:6731691
Abstract

Temporary occlusion of hepatic inflow, namely, the Pringle maneuver, was adopted for 15 patients with liver cirrhosis who underwent partial hepatectomy. The warm ischemia time ranged from 2 to 32 minutes with an average of 19 minutes. The procedure did not cause any harmful effects on systemic hemodynamic and postoperative liver function. The results in our patients were compared with those of 15 comparable control patients who had been operated on over the same period of time without inflow obstruction. The Pringle maneuver significantly diminished the estimated blood loss during surgery, intraoperative and postoperative complications, and suppressed the operative mortality rate from 20 percent to 0.

摘要

对15例接受肝部分切除术的肝硬化患者采用了肝血流的临时阻断,即Pringle手法。热缺血时间为2至32分钟,平均为19分钟。该操作未对全身血流动力学和术后肝功能造成任何有害影响。将我们患者的结果与同期接受手术但未进行血流阻断的15例对照患者的结果进行了比较。Pringle手法显著减少了手术期间的估计失血量、术中和术后并发症,并将手术死亡率从20%降至0。

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引用本文的文献

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Effect of the pringle maneuver on tumor recurrence of hepatocellular carcinoma after curative resection (EPTRH): a randomized, prospective, controlled multicenter trial.阻断入肝血流对根治性切除术后肝细胞肝癌复发的影响(EPTRH):一项随机、前瞻性、对照、多中心临床试验。
BMC Cancer. 2012 Aug 3;12:340. doi: 10.1186/1471-2407-12-340.
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J Anesth. 1991 Jan;5(1):43-7. doi: 10.1007/s0054010050043.
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The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors.
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Liver resection without total vascular exclusion: hazardous or beneficial? An analysis of our experience.不进行全肝血管阻断的肝切除术:危险还是有益?基于我们经验的分析。
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Pringle maneuver during hepatic resection induces inflammatory cytokines.
Dig Dis Sci. 1996 Dec;41(12):2459-60. doi: 10.1007/BF02100143.
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