头孢磺啶在囊性纤维化患者中的单剂量药代动力学。
Single-dose pharmacokinetics of cefsulodin in patients with cystic fibrosis.
作者信息
Reed M D, Stern R C, Yamashita T S, Ackers I, Myers C M, Blumer J L
出版信息
Antimicrob Agents Chemother. 1984 May;25(5):579-81. doi: 10.1128/AAC.25.5.579.
Abstract
The single-dose pharmacokinetics of cefsulodin were evaluated in 12 patients with cystic fibrosis. Each patient received 3 g of cefsulodin intravenously over 30 min. Multiple plasma and urine samples were obtained during the 6-h study period for the determination of cefsulodin. Pharmacokinetic parameters were determined by model-independent methods. Mean values for t1/2, Vss, and CLp were 1.53 h, 0.242 liters/kg, and 117.3 ml/min per 1.73 m2, respectively. Six-hour urine recovery revealed 73.2% of the administered dose with a corresponding cefsulodin urinary clearance of 75.1 ml/min. These pharmacokinetic data in patients with cystic fibrosis appear consistent with data reported for unaffected individuals.
摘要
对12例囊性纤维化患者进行了头孢磺啶单剂量药代动力学评估。每位患者在30分钟内静脉注射3g头孢磺啶。在6小时的研究期间采集多个血浆和尿液样本以测定头孢磺啶。药代动力学参数通过非模型依赖方法确定。t1/2、Vss和CLp的平均值分别为1.53小时、0.242升/千克和每1.73平方米117.3毫升/分钟。6小时尿液回收率显示给药剂量的73.2%，相应的头孢磺啶尿清除率为75.1毫升/分钟。这些囊性纤维化患者的药代动力学数据似乎与未受影响个体报告的数据一致。
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