阿洛西林与哌拉西林和羧苄西林对来自四个不同医疗中心的6797株细菌分离株的体外活性比较。
In vitro activity of apalcillin compared with those of piperacillin and carbenicillin against 6,797 bacterial isolates from four separate medical centers.
作者信息
Barry A L, Jones R N, Ayers L W, Gavan T L, Gerlach E H, Sommers H M
出版信息
Antimicrob Agents Chemother. 1984 May;25(5):669-71. doi: 10.1128/AAC.25.5.669.
Abstract
Quantitative susceptibility tests were performed in four separate medical centers, in which apalcillin was compared with piperacillin and carbenicillin. Data from tests of 6,797 isolates confirmed that apalcillin and piperacillin had nearly identical spectra of activity but that apalcillin was significantly more active against Pseudomonas aeruginosa (MIC required to inhibit 90% of strains, 2.0 versus 64 micrograms/ml) and Acinetobacter calcoaceticus subsp. anitratus (MIC required to inhibit 90% of strains, 2.0 versus 16 micrograms/ml). Against 166 anaerobic bacterial isolates, apalcillin demonstrated in vitro activity.
摘要
在四个不同的医学中心进行了定量药敏试验，将阿帕西林与哌拉西林和羧苄西林进行比较。对6797株分离菌的测试数据证实，阿帕西林和哌拉西林的活性谱几乎相同，但阿帕西林对铜绿假单胞菌（抑制90%菌株所需的MIC，2.0对64微克/毫升）和醋酸钙不动杆菌亚种鲍曼不动杆菌（抑制90%菌株所需的MIC，2.0对16微克/毫升）的活性明显更强。针对166株厌氧细菌分离株，阿帕西林表现出体外活性。
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