粘质沙雷氏菌对β-内酰胺类抗生素的耐药性：苄青霉素、阿帕西林、头孢唑林和头孢唑肟的作用比较。
beta-Lactam resistance in Serratia marcescens: comparison of action of benzylpenicillin, Apalcillin, Cefazolin, and ceftizoxime.
作者信息
Takata N, Suginaka H, Kotani S, Ogawa M, Kosaki G
出版信息
Antimicrob Agents Chemother. 1981 Mar;19(3):397-401. doi: 10.1128/AAC.19.3.397.
The intrinsic mechanisms of resistance to beta-lactam antibiotics in Serratia marcescens IFO 12648 were investigated, comparing the action of benzylpenicillin, apalcillin, cefazolin, and ceftizoxime. The minimal inhibitory concentrations for this strain were 1,600, 3.13, 6,400, and 0.05 microgram/ml, respectively. The addition of ethylenediaminetetraacetic acid markedly reduced the minimal inhibitory concentrations of benzylpenicillin and cefazolin, whereas those of apalcillin and ceftizoxime were not influenced. S. marcescens IFO 12648 produced only a low level of beta-lactamase activity constitutively, and the production was considerably increased by the addition of benzylpenicillin. Cefazolin was hydrolyzed rapidly by beta-lactamase activity, whereas benzylpenicillin, apalcillin, and ceftizoxime were poorly hydrolyzed. Peptidoglycan synthesis in ether-treated strain IFO 12646 cells was inhibited by a concentration of ceftizoxime markedly lower than that of cefazolin and by a concentration of apalcillin moderately lower than that of benzylpenicillin.
研究了粘质沙雷氏菌IFO 12648对β-内酰胺类抗生素耐药的内在机制，比较了苄青霉素、阿帕西林、头孢唑林和头孢替安的作用。该菌株对上述抗生素的最低抑菌浓度分别为1600、3.13、6400和0.05微克/毫升。添加乙二胺四乙酸可显著降低苄青霉素和头孢唑林的最低抑菌浓度，而阿帕西林和头孢替安的最低抑菌浓度则不受影响。粘质沙雷氏菌IFO 12648组成性产生的β-内酰胺酶活性水平较低，添加苄青霉素后其产量显著增加。头孢唑林可被β-内酰胺酶活性快速水解，而苄青霉素、阿帕西林和头孢替安则不易被水解。醚处理菌株IFO 12646细胞中的肽聚糖合成被头孢替安浓度显著低于头孢唑林以及阿帕西林浓度适度低于苄青霉素的情况所抑制。
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