阿帕西林和头孢匹胺在实验性肺炎球菌脑膜炎中的药代动力学及细菌学疗效
Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis.
作者信息
Sato K, Shelton S, Nelson J D
出版信息
Antimicrob Agents Chemother. 1984 Oct;26(4):578-9. doi: 10.1128/AAC.26.4.578.
Abstract
Rabbits with experimentally induced pneumococcal meningitis were given single 25-mg/kg doses of apalcillin or cefpiramide. Mean percentages of the drug concentration in cerebrospinal fluid versus that in blood serum were 7.6% with apalcillin and 3.9% with cefpiramide. Bactericidal activity in cerebrospinal fluid resulted in mean reductions of from 4 to 5 log10 CFU/ml, and cerebrospinal fluid cultures became sterile for four of six animals treated with each drug.
摘要
给实验性诱发肺炎球菌性脑膜炎的兔子单次静脉注射阿帕西林或头孢匹胺，剂量均为25mg/kg。阿帕西林和头孢匹胺在脑脊液中的药物浓度与血清中的药物浓度的平均百分比分别为7.6%和3.9%。脑脊液中的杀菌活性使细菌数量平均减少4至5个对数10CFU/ml，用每种药物治疗的六只动物中有四只脑脊液培养变为无菌。
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Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis.阿帕西林和头孢匹胺在实验性肺炎球菌脑膜炎中的药代动力学及细菌学疗效
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本文引用的文献
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Antimicrob Agents Chemother. 1982 Jun;21(6):906-11. doi: 10.1128/AAC.21.6.906.
2
In vitro activity of apalcillin compared with those of piperacillin and carbenicillin against 6,797 bacterial isolates from four separate medical centers.阿洛西林与哌拉西林和羧苄西林对来自四个不同医疗中心的6797株细菌分离株的体外活性比较。
Antimicrob Agents Chemother. 1984 May;25(5):669-71. doi: 10.1128/AAC.25.5.669.
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In vitro antibacterial activity of cefpiramide.头孢匹胺的体外抗菌活性。
Antimicrob Agents Chemother. 1984 Mar;25(3):368-72. doi: 10.1128/AAC.25.3.368.
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