Tanaka N, Ohida J, Ono M, Yoshiwara H, Beika T, Terasawa A, Yamada J, Morioka S, Mannami T, Orita K
Gan To Kagaku Ryoho. 1984 Jun;11(6):1303-6.
The natural killer (NK) activity of peripheral blood lymphocytes from 18 cancer patients was studied prior to and after multiple administration of organo-germanium compound (Ge-132). In successive oral administration of Ge-132 at a dose of 1000 mg/day for 10 days, NK-activity of patients was augmented at 3 days, but by 10 days, depression of NK activity was observed in all cases. In intermittent oral administration of Ge-132, however, more than half of the patients with augmented NK activity at day 3 maintained the high activity level at day 10. This result suggests the superiority of intermittent administration of Ge-132 for clinical use.
对18例癌症患者外周血淋巴细胞的自然杀伤（NK）活性在多次给予有机锗化合物（Ge-132）之前和之后进行了研究。以每天1000毫克的剂量连续口服Ge-132，持续10天，患者的NK活性在第3天增强，但到第10天，所有病例均观察到NK活性降低。然而，在间歇口服Ge-132时，超过一半在第3天NK活性增强的患者在第10天维持了高活性水平。这一结果表明Ge-132间歇给药在临床应用上具有优越性。
