Tanaka N, Gotoh K, Kobayashi G, Gouchi A, Orita K
Department of Surgery, Iwakuni National Hospital, Japan.
Int J Immunopharmacol. 1994 Feb;16(2):131-5. doi: 10.1016/0192-0561(94)90069-8.
It has been demonstrated that natural killer (NK) cell activity of lymphnode lymphocytes (LNL) is very low and hardly augmented by interferon. In this study, OK-432 was injected into the gastric cancer mass through endoscopy one week before the operation, through which NK activity of LNL was significantly increased. A single cell assay could divide the OK-432-injected patients into two groups; responder and non-responder. In responders, the increased activity induced by OK-432 was found also in the distal lymphnodes.
