Guidoin R, Snyder R, Martin L, Botzko K, Marois M, Awad J, King M, Domurado D, Bedros M, Gosselin C
Ann Thorac Surg. 1984 Jun;37(6):457-65. doi: 10.1016/s0003-4975(10)61131-9.
Coating a knitted polyester arterial prosthesis with cross-linked albumin fills the interstices of the graft and relieves the surgeon of the necessity to preclot . This is of particular value in patients whose blood clotting properties are hypercoagulable, or hypocoagulable . In addition, such prostheses require less handling, which can lower the risk of bacteremic colonization and shorten the operative time. The in vivo behavior of the implanted albuminated prosthesis in the thoracic aorta of dogs is similar to that of preclotted grafts, although the sequences of early healing are different. The preclotted graft develops a continuous, thick thrombotic matrix on its luminal surface during the first 4 hours of implantation. Following the initiation of the fibrinolytic mechanism 24 to 48 hours postoperatively, this thrombotic deposit quickly recedes , leaving blood cells and platelets adhering here and there to the prosthetic surface. In comparison, the albuminated coating is not associated with major early thrombotic deposits. The albumin remains visible between the filaments during the first 2 weeks of implantation. Both treated and control grafts contain numerous thrombi on their inner surface after 1 to 2 weeks. After 1, 3, and 6 months, both implants are well encapsulated and present a glistening and continuous luminal surface. This excellent healing, however, can be compromised should the graft adhere too closely to the animal's lungs.+2
用交联白蛋白包裹针织聚酯动脉假体可填充移植物的间隙，使外科医生无需进行预凝处理。这对于凝血特性为高凝或低凝的患者尤为重要。此外，这种假体需要的操作较少，可降低细菌定植的风险并缩短手术时间。植入犬胸主动脉的白蛋白化假体在体内的行为与预凝移植物相似，尽管早期愈合的顺序不同。预凝移植物在植入后的前4小时内在其管腔表面形成连续、厚实的血栓基质。术后24至48小时纤维蛋白溶解机制启动后，这种血栓沉积物迅速消退，血细胞和血小板零星附着在假体表面。相比之下，白蛋白涂层不会形成主要的早期血栓沉积物。在植入的前2周内，细丝之间仍可见白蛋白。1至2周后，处理过的移植物和对照移植物的内表面都有大量血栓。1、3和6个月后，两种植入物都被良好地包裹，管腔表面光滑且连续。然而，如果移植物与动物的肺贴得太近，这种良好的愈合可能会受到影响。
