Finnerty N A, Buzdar A U, Blumenschein G R
Arch Intern Med. 1984 Jun;144(6):1217-9.
Between 1975 and 1983, sixteen patients with a history of irradiation at an early age to the head, neck, or chest areas for a variety of conditions in whom breast cancer subsequently developed were seen at out institute. The median latent period between the irradiation and the development of breast cancer was 420 months. The distribution of patients by stage of the disease and the median age at diagnosis of this subgroup was similar to the breast cancer observed in the general population. The subsequent course of this disease was also similar to the breast cancer observed in the general population. A substantial number of women have been exposed to irradiation at a young age, and these women are at a higher risk of having breast cancer develop. These women should be closely observed to discover the disease in an early curable stage.
1975年至1983年间，我院收治了16例早年因各种疾病接受头部、颈部或胸部放疗，随后发生乳腺癌的患者。放疗与乳腺癌发生之间的中位潜伏期为420个月。该亚组患者按疾病分期的分布及诊断时的中位年龄与一般人群中观察到的乳腺癌相似。该疾病的后续病程也与一般人群中观察到的乳腺癌相似。大量女性在年轻时接受过放疗，这些女性患乳腺癌的风险更高。应密切观察这些女性，以便在可治愈的早期阶段发现疾病。
