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低剂量电离辐射所致乳腺癌风险:对三组受照女性人群的平行分析结果

Breast cancer risk from low-dose exposures to ionizing radiation: results of parallel analysis of three exposed populations of women.

作者信息

Land C E, Boice J D, Shore R E, Norman J E, Tokunaga M

出版信息

J Natl Cancer Inst. 1980 Aug;65(2):353-76.

PMID:6931253
Abstract

Breast cancer incidence data were analyzed from three populations of women exposed to ionizing radiation: survivors of the Hiroshima and Nagasaki atomic bombs, patients in Massachusetts tuberculosis sanitoria who were exposed to multiple chest fluoroscopies, and patients treated by X-rays for acute postpartum mastitis in Rochester, New York. Parallel analyses by radiation dose, age at exposure, and time after exposure suggested that risk of radiation-induced cancer increased approximately linearly with increasing dose and was heavily dependent on age at exposure; however, the risk was otherwise remarkably similar among the three population, at least for age 10-40 years at exposure, and followed the same temporal pattern of occurrence as did breast cancer incidence in nonexposed women of similar ages.

摘要

对三组暴露于电离辐射的女性群体的乳腺癌发病率数据进行了分析

广岛和长崎原子弹爆炸的幸存者、马萨诸塞州结核病疗养院中接受多次胸部荧光透视检查的患者,以及纽约罗切斯特因急性产后乳腺炎接受X射线治疗的患者。通过辐射剂量、暴露时年龄和暴露后时间进行的平行分析表明,辐射诱发癌症的风险随剂量增加大致呈线性增加,并且严重依赖于暴露时的年龄;然而,至少对于暴露时年龄在10 - 40岁之间的人群,这三组人群中的风险在其他方面显著相似,并且其发生的时间模式与年龄相仿的未暴露女性的乳腺癌发病率相同。

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