Rubler S, Fisher V J, Schreiber S S, Rothschild M A, Dobin A S
Arch Intern Med. 1984 Jul;144(7):1386-91.
Left ventricular ejection times ( LVETs ) were obtained in a group of 20 control subjects (group 1) during maximal treadmill exercise testing, using a Bruce protocol, and in conjunction with myocardial scintigraphy. Heart rates (HRs) and LVETs were recorded during standing rest, each minute of exercise, and for eight minutes in the postexercise period. A linear regression equation was constructed and separate correction factors of 1.04 X HR + observed LVET (correlation coefficient, -.86) for the exercise period and 0.73 X HR + LVET (correlation coefficient, -.71) for the postexercise period were derived. The LVETs were also recorded in 31 subjects with positive ECGs and defects on myocardial scanning with thallous chloride TL201 (group 2) during a similar exercise protocol. Comparison of groups 1 and 2 disclosed that the former had a higher HR and shorter LVET than the latter at peak effort (consonant with the significantly longer duration of exercise achieved by the control subjects). The LVETs in group 1 remained significantly shorter than that of group 2 through the fifth minute postexercise. In the postexercise period, the LVET indexes were significantly shorter in group 1 than group 2 at 1, 3, and 5 minutes. Subjects with presumptive coronary disease (positive ECG and defects on thallium 201 scanning) not only have a decreased exercise tolerance and HR, but after exercise, their ejection times are substantially longer than in normal subjects. This may be attributed to a slower rate of ejection in patients with coronary disease when venous pooling on quiet standing after exercise delivers a smaller volume to the heart. In normal subjects, the lesser volume may be ejected more rapidly.
在一组20名对照受试者（第1组）进行最大运动平板试验期间，采用布鲁斯方案并结合心肌闪烁显像术，获取左心室射血时间（LVETs）。在静息站立时、运动的每分钟以及运动后8分钟记录心率（HRs）和LVETs。构建了一个线性回归方程，并得出运动期间的单独校正因子为1.04×HR + 观察到的LVET（相关系数，-0.86），运动后期间的校正因子为0.73×HR + LVET（相关系数，-0.71）。在31名心电图阳性且用氯化铊Tl201心肌扫描有缺损的受试者（第2组）中，采用类似的运动方案记录LVETs。第1组和第2组的比较显示，在峰值运动时，前者的心率较高而LVET较短（这与对照受试者实现的明显更长运动持续时间一致）。运动后第5分钟，第1组的LVETs仍显著短于第2组。在运动后期间，第1组在运动后1、3和5分钟时的LVET指数显著短于第2组。疑似患有冠心病（心电图阳性且铊201扫描有缺损）的受试者不仅运动耐量和心率降低，而且运动后他们的射血时间比正常受试者长得多。这可能归因于冠心病患者射血速度较慢，因为运动后安静站立时静脉淤血使心脏获得的血量减少。在正常受试者中，较少的血量可能会更快地射出。
