冠心病的范围和严重程度。通过氯化铊Tl 201心肌灌注扫描测定并与运动心电图进行比较。

Extent and severity of coronary heart disease. Determinations by thallous chloride Tl 201 myocardial perfusion scanning and comparison with stress electrocardiography.

作者信息

Bodenheimer M B, Banka V S, Fooshee C M, Helfant R H

出版信息

Arch Intern Med. 1979 Jun;139(6):630-4. doi: 10.1001/archinte.139.6.630.

DOI:10.1001/archinte.139.6.630

Abstract

Rest and exercise ECGs are the most widely used "noninvasive" tests for detecting coronary heart disease, but their sensitivity and specificity are suboptimal. Therefore, the diagnostic value of myocardial perfusion scanning using thallous chloride Tl 201 during rest and stress electrocardiography was examined in 95 patients with a chest discomfort syndrome. Overall, thallous chloride Tl 201 perfusion scanning had a sensitivity of 75% and a specificity of 91% for coronary heart disease compared with 56% sensitivity and 86% specificity with exercise-induced ST segment depression on the ECG. Combining rest and stress ECGs resulted in a sensitivity of 71%. In patients with coronary heart disease, perfusion scanning had a sensitivity of 93% for asynergy compared with 58% for exercise-induced ECG ST depression. Rest and stress myocardial perfusion scanning with thallous chloride Tl 201 provides improved sensitivity with good specificity in the diagnosis of coronary heart disease compared with exercise electrocardiography alone.

摘要

静息心电图和运动心电图是检测冠心病最广泛使用的“非侵入性”检查，但它们的敏感性和特异性并不理想。因此，对95例胸部不适综合征患者进行了静息和负荷心电图检查时使用氯化铊Tl 201进行心肌灌注扫描的诊断价值研究。总体而言，与运动诱发心电图ST段压低时敏感性为56%、特异性为86%相比，氯化铊Tl 201灌注扫描对冠心病的敏感性为75%，特异性为91%。联合静息和负荷心电图的敏感性为71%。在冠心病患者中，灌注扫描对心肌运动不协调的敏感性为93%，而运动诱发心电图ST段压低的敏感性为58%。与单独的运动心电图相比，静息和负荷心肌灌注扫描使用氯化铊Tl 201在冠心病诊断中具有更高的敏感性和良好的特异性。