Gur R E, Skolnick B E, Gur R C, Caroff S, Rieger W, Obrist W D, Younkin D, Reivich M
Arch Gen Psychiatry. 1984 Jul;41(7):695-9. doi: 10.1001/archpsyc.1984.01790180065008.
Regional cerebral blood flow was measured during resting baseline and the performance of a verbal and a spatial task in 14 medicated depressives and 25 matched controls. Overall resting flows did not differ, nor were there hemispheric or anteroposterior differences between patients and controls for resting flows. Differences between patients and controls were evident during cognitive activity, and the effects were different for male and female patients. Depressed female patients had higher than normal flows in all conditions, whereas depressed male patients had lower than normal resting flows, which increased to normal during cognitive activity. Their anterior flows increased for the verbal task but not for the spatial task.
在14名接受药物治疗的抑郁症患者和25名匹配的对照组中，测量了静息基线状态以及进行语言和空间任务时的局部脑血流量。总体静息血流量没有差异，患者和对照组在静息血流量方面也没有半球或前后差异。患者和对照组之间的差异在认知活动期间很明显，并且男性和女性患者的影响不同。抑郁的女性患者在所有情况下的血流量都高于正常水平，而抑郁的男性患者静息血流量低于正常水平，在认知活动期间增加到正常水平。他们的前脑血流量在语言任务时增加，但在空间任务时没有增加。
