Winchester J F, Rahman A, Tilstone W J, Kessler A, Mortensen L, Schreiner G E, Schein P S
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1787-93.
Adriamycin adsorption to four sorbents, uncoated activated charcoal, acrylic hydrogel-coated activated charcoal, a polystyrene non-ionic resin, and a pyrolized resin, was determined in vitro in aqueous and plasma solutions. Uncoated charcoal and pyrolized resin were most efficient in removing Adriamycin from these solutions. Four hours after an iv bolus of Adriamycin (2.5 mg/kg) to beagle dogs, acrylic hydrogel-coated activated charcoal hemoperfusion was performed. Extraction of Adriamycin averaged 43% throughout the 3-hour hemoperfusion period and resulted in a 20-fold increase in total body elimination of Adriamycin but plasma drug concentrations returned towards control values following hemoperfusion. Pharmacokinetic analysis of plasma Adriamycin profiles suggested that reduction of tissue concentrations of Adriamycin could be attained if hemoperfusion periods were extended. It is suggested that hemoperfusion may be useful in reducing blood levels of Adriamycin in patients with hepatic disease or accidental overdosage, but that reduction of tissue levels of Adriamycin would require extended or repeated hemoperfusion treatments.
在体外的水性溶液和血浆溶液中测定了阿霉素在四种吸附剂上的吸附情况，这四种吸附剂分别是未涂层的活性炭、丙烯酸水凝胶涂层的活性炭、聚苯乙烯非离子树脂和热解树脂。未涂层的活性炭和热解树脂在从这些溶液中去除阿霉素方面效率最高。对小猎犬静脉注射阿霉素（2.5毫克/千克）4小时后，进行了丙烯酸水凝胶涂层活性炭血液灌流。在整个3小时的血液灌流期间，阿霉素的提取率平均为43%，导致阿霉素的全身消除增加了20倍，但血液灌流后血浆药物浓度又恢复到对照值。血浆阿霉素曲线的药代动力学分析表明，如果延长血液灌流时间，可以降低阿霉素的组织浓度。有人提出，血液灌流可能有助于降低肝病患者或意外过量用药患者的阿霉素血药水平，但降低阿霉素的组织水平需要延长或重复进行血液灌流治疗。
