Bendahmane M, Chauvet Monges A M, Braguer D, Peyrot V, Crevat A
Biochem Pharmacol. 1984 Jun 15;33(12):1937-40. doi: 10.1016/0006-2952(84)90551-3.
The in vitro effects of some nitroimidazoles (metronidazole, ornidazole) and their metabolites on microtubule formation have been tested. Cyclic metabolites are without effect. Metabolites proceeding from cleavage of the imidazole ring inhibit microtubule formation and reduce the polymerization rate of tubulin. This inhibitory effect might be correlated to some of the side-effects of these drugs. Isaxonine phosphate corrects this effect.
已测试了某些硝基咪唑类药物（甲硝唑、奥硝唑）及其代谢产物对微管形成的体外作用。环状代谢产物无作用。咪唑环裂解产生的代谢产物抑制微管形成并降低微管蛋白的聚合速率。这种抑制作用可能与这些药物的某些副作用相关。磷酸异沙索宁可纠正这种作用。
