Wilks J W
Biol Reprod. 1984 May;30(4):886-93. doi: 10.1095/biolreprod30.4.886.
Prior work has shown that 5-oxa-17-phenyl-18,19,20- trinor prostaglandin F1 alpha methyl ester (PGF-analog) inhibits luteal progesterone secretion, but does not shorten menstrual cycles in human chorionic gonadotropin (hCG)-treated, nonpregnant monkeys. This report demonstrates that a combination treatment of PGF-analog and mestranol not only reduces blood progesterone concentrations in the hCG-treated monkey, but also results in a significant shortening of menstrual cycles. The corpus luteum-inhibiting activity of PGF-analog in hCG-treated, nonpregnant monkeys was not enhanced by simultaneous administration of nonestrogenic steroids (norethisterone, oxymetholone, azastene , 17 alpha-allyl-3-methoxy-1,3,5(10)- estratrien-17 beta-ol). Most importantly, pregnancy was interrupted in 11 or 12 monkeys when PGF-analog and mestranol were administered on Day 28 of fertile menstrual cycles; this abortifacient activity of the prostaglandin-estrogen treatment was not prevented by concomitant administration of progesterone. Administration of PGF-analog and mestranol in the third trimester terminated pregnancy in only 1 of 3 monkeys. The data indicate that a combination treatment of PGF-analog and mestranol is highly effective for the termination of early pregnancy in the monkey. Although PGF-analog and mestranol clearly inhibit the monkey corpus luteum, it is unlikely that this activity is essential for the abortifacient activity of the prostaglandin-estrogen treatment.
先前的研究表明，5-氧杂-17-苯基-18,19,20-三降前列腺素F1α甲酯（PGF类似物）可抑制黄体孕酮分泌，但在人绒毛膜促性腺激素（hCG）处理的未孕猴中不会缩短月经周期。本报告表明，PGF类似物与炔雌醇甲醚联合治疗不仅可降低hCG处理猴的血孕酮浓度，还可显著缩短月经周期。在hCG处理的未孕猴中，同时给予非雌激素类甾体（炔诺酮、羟甲烯龙、阿扎斯丁、17α-烯丙基-3-甲氧基-1,3,5(10)-雌甾三烯-17β-醇）并不能增强PGF类似物的黄体抑制活性。最重要的是，在可育月经周期的第28天给予PGF类似物和炔雌醇甲醚时，11或12只猴的妊娠被中断；前列腺素-雌激素治疗的这种堕胎活性不会因同时给予孕酮而受到阻止。在妊娠晚期给予PGF类似物和炔雌醇甲醚时，3只猴中只有1只终止了妊娠。数据表明，PGF类似物与炔雌醇甲醚联合治疗对猴早期妊娠的终止非常有效。尽管PGF类似物和炔雌醇甲醚明显抑制猴黄体，但这种活性不太可能是前列腺素-雌激素治疗堕胎活性所必需的。
