• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ATP、ADP和AMP的硫代磷酸酯类似物对豚鼠结肠带和膀胱的作用。

Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder.

作者信息

Burnstock G, Cusack N J, Meldrum L A

出版信息

Br J Pharmacol. 1984 Jun;82(2):369-74. doi: 10.1111/j.1476-5381.1984.tb10771.x.

DOI:10.1111/j.1476-5381.1984.tb10771.x
PMID:6733363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1987028/
Abstract

Phosphorothioate analogues of ATP, ADP and AMP were tested on the guinea-pig taenia coli and urinary bladder. The Rp diastereoisomers of the phosphorothioate analogues, ATP-alpha-S and ADP-alpha-S were respectively 7 and 3 times more effective than the Sp diastereoisomers in causing relaxation of the taenia coli. No stereoselectivity was observed for the diastereoisomers of ATP-beta-S. In guinea-pig bladder, no stereoselectivity was observed for any of the phosphorothioate analogues. These results show that P2-purinoceptors mediating inhibitory responses in the guinea-pig taenia coli show marked stereoselectivity, while P2-purinoceptors mediating excitatory responses in the guinea-pig bladder show little stereoselectivity.

摘要

对ATP、ADP和AMP的硫代磷酸酯类似物在豚鼠结肠带和膀胱上进行了测试。硫代磷酸酯类似物ATP-α-S和ADP-α-S的Rp非对映异构体在引起结肠带松弛方面分别比Sp非对映异构体有效7倍和3倍。对于ATP-β-S的非对映异构体未观察到立体选择性。在豚鼠膀胱中，对任何硫代磷酸酯类似物均未观察到立体选择性。这些结果表明，介导豚鼠结肠带抑制性反应的P2嘌呤受体表现出明显的立体选择性，而介导豚鼠膀胱兴奋性反应的P2嘌呤受体几乎没有立体选择性。

相似文献

1
Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder.ATP、ADP和AMP的硫代磷酸酯类似物对豚鼠结肠带和膀胱的作用。
Br J Pharmacol. 1984 Jun;82(2):369-74. doi: 10.1111/j.1476-5381.1984.tb10771.x.
2
Studies on the stereoselectivity of the P2-purinoceptor.P2嘌呤受体的立体选择性研究。
Br J Pharmacol. 1983 Aug;79(4):907-13. doi: 10.1111/j.1476-5381.1983.tb10535.x.
3
Studies on the stereoselectivity of the P2-purinoceptor on the guinea-pig vas deferens.豚鼠输精管上P2嘌呤受体的立体选择性研究。
Br J Pharmacol. 1985 Feb;84(2):431-4. doi: 10.1111/j.1476-5381.1985.tb12927.x.
4
The activity of phosphorothioate analogues of ATP in various smooth muscle systems.ATP的硫代磷酸酯类似物在各种平滑肌系统中的活性。
Br J Pharmacol. 1985 Jan;84(1):165-73.
5
Relaxation of isolated taenia coli of guinea-pig by enantiomers of 2-azido analogues of adenosine and adenine nucleotides.腺苷和腺嘌呤核苷酸的2-叠氮类似物对映体对豚鼠离体结肠带的舒张作用
Br J Pharmacol. 1979 Sep;67(1):153-8.
6
Adenosine 5'-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle.腺苷5'-(2-氟二磷酸)是一种选择性激动剂，作用于介导平滑肌舒张的P2嘌呤受体。
Eur J Pharmacol. 1988 Feb 16;147(1):131-6. doi: 10.1016/0014-2999(88)90642-5.
7
L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli.L-AMP-PCP是豚鼠膀胱中的一种ATP受体激动剂，对结肠带无活性。
Eur J Pharmacol. 1985 Jan 22;108(2):197-200. doi: 10.1016/0014-2999(85)90726-5.
8
Pharmacological effects of isopolar phosphonate analogues of ATP on P2-purinoceptors in guinea-pig taenia coli and urinary bladder.ATP的等极性膦酸酯类似物对豚鼠结肠带和膀胱中P2嘌呤受体的药理作用。
Br J Pharmacol. 1987 Apr;90(4):791-5. doi: 10.1111/j.1476-5381.1987.tb11233.x.
9
Suramin antagonizes responses to P2-purinoceptor agonists and purinergic nerve stimulation in the guinea-pig urinary bladder and taenia coli.苏拉明可拮抗豚鼠膀胱和平滑肌对P2嘌呤受体激动剂及嘌呤能神经刺激的反应。
Br J Pharmacol. 1990 Mar;99(3):617-21. doi: 10.1111/j.1476-5381.1990.tb12979.x.
10
Comparison of the inhibitory effects on the guinea-pig taenia coli of adenine nucleotides and adenosine in the presence and absence of dipyridamole.在有和没有双嘧达莫存在的情况下，腺嘌呤核苷酸和腺苷对豚鼠结肠带的抑制作用比较。
Eur J Pharmacol. 1975 Jun-Jul;32(02):324-8. doi: 10.1016/0014-2999(75)90299-x.

引用本文的文献

1
Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function.靶向嘌呤能受体 P2Y12 和 A2b 拮抗调节膀胱功能。
JCI Insight. 2019 Aug 22;4(16):122112. doi: 10.1172/jci.insight.122112.
2
ADP-induced bladder contractility is mediated by P2Y12 receptor and temporally regulated by ectonucleotidases and adenosine signaling.二磷酸腺苷（ADP）诱导的膀胱收缩由P2Y12受体介导，并受外核苷酸酶和腺苷信号的时间调节。
FASEB J. 2014 Dec;28(12):5288-98. doi: 10.1096/fj.14-255885. Epub 2014 Sep 10.
3
Purinergic signalling in the urinary tract in health and disease.健康与疾病状态下尿路中的嘌呤能信号传导。
Purinergic Signal. 2014 Mar;10(1):103-55. doi: 10.1007/s11302-013-9395-y. Epub 2013 Nov 22.
4
Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes.作为P(2)嘌呤受体激动剂的三磷酸腺苷-5'-衍生物的构效关系：P(2X)和P(2Y)亚型内的异质性
Drug Dev Res. 1994 Mar;31(3):206-219. doi: 10.1002/ddr.430310308. Epub 2004 Oct 5.
5
The activity of phosphorothioate analogues of ATP in various smooth muscle systems.ATP的硫代磷酸酯类似物在各种平滑肌系统中的活性。
Br J Pharmacol. 1985 Jan;84(1):165-73.
6
Extracellular ATP: effects, sources and fate.细胞外ATP：作用、来源及去向
Biochem J. 1986 Jan 15;233(2):309-19. doi: 10.1042/bj2330309.
7
Studies on the stereoselectivity of the P2-purinoceptor on the guinea-pig vas deferens.豚鼠输精管上P2嘌呤受体的立体选择性研究。
Br J Pharmacol. 1985 Feb;84(2):431-4. doi: 10.1111/j.1476-5381.1985.tb12927.x.
8
Proceedings of the British Pharmacological Society. University of Manchester, 13-15 September 1989.英国药理学会会议记录。曼彻斯特大学，1989年9月13日至15日。
Br J Pharmacol. 1989 Dec;98 Suppl(Suppl):775P-952P.
9
Adenosine-5'-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas.腺苷-5'-O-(2-硫代二磷酸)是一种强效激动剂，作用于P2嘌呤受体，介导胰岛素从灌注大鼠胰腺中分泌。
Br J Pharmacol. 1991 Mar;102(3):627-30. doi: 10.1111/j.1476-5381.1991.tb12223.x.

本文引用的文献

1
Effects of RP and SP diastereoisomers of adenosine 5'-O-(1-thiodiphosphate) on human platelets.腺苷5'-O-(1-硫代二磷酸)的RP和SP非对映异构体对人血小板的作用。
Br J Pharmacol. 1981 Jun;73(2):409-12. doi: 10.1111/j.1476-5381.1981.tb10437.x.
2
Evidence in support of the P1/P2 purinoceptor hypothesis in the guinea-pig taenia coli.支持豚鼠结肠带中P1/P2嘌呤受体假说的证据。
Br J Pharmacol. 1981 Jul;73(3):617-24. doi: 10.1111/j.1476-5381.1981.tb16796.x.
3
Studies on the stereoselectivity of the P2-purinoceptor.P2嘌呤受体的立体选择性研究。
Br J Pharmacol. 1983 Aug;79(4):907-13. doi: 10.1111/j.1476-5381.1983.tb10535.x.
4
Adenosine 5-diphosphate antagonists and human platelets: no evidence that aggregation and inhibition of stimulated adenylate cyclase are mediated by different receptors.腺苷5-二磷酸拮抗剂与人类血小板：无证据表明聚集和刺激型腺苷酸环化酶的抑制作用由不同受体介导。
Br J Pharmacol. 1982 May;76(1):221-7. doi: 10.1111/j.1476-5381.1982.tb09210.x.
5
Effect of apamin on the electrical responses of smooth muscle to adenosine 5'-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation.蜂毒明肽对平滑肌对5'-三磷酸腺苷及对非肾上腺素能、非胆碱能神经刺激的电反应的影响。
Neuroscience. 1980;5(5):853-9. doi: 10.1016/0306-4522(80)90154-2.
6
Non-cholinergic transmission by post-ganglionic motor neurones in the mammalian bladder.哺乳动物膀胱中节后运动神经元的非胆碱能传递。
J Physiol. 1970 Oct;210(3):761-83. doi: 10.1113/jphysiol.1970.sp009240.
7
Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide.阿托品抵抗性膀胱兴奋：通过释放嘌呤核苷酸的神经进行传递的可能性。
Br J Pharmacol. 1972 Mar;44(3):451-61. doi: 10.1111/j.1476-5381.1972.tb07283.x.
8
Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli.腺嘌呤核苷酸类似物对离体豚鼠结肠带的抑制作用。
J Pharmacol Exp Ther. 1975 Dec;195(3):540-8.
9
Comparison of the inhibitory effects on the guinea-pig taenia coli of adenine nucleotides and adenosine in the presence and absence of dipyridamole.在有和没有双嘧达莫存在的情况下，腺嘌呤核苷酸和腺苷对豚鼠结肠带的抑制作用比较。
Eur J Pharmacol. 1975 Jun-Jul;32(02):324-8. doi: 10.1016/0014-2999(75)90299-x.
10
Divalent cation-dependent stereospecificity of adenosine 5'-O-(2-thiotriphosphate) in the hexokinase and pyruvate kinase reactions. The absolute stereochemistry of the diastereoisomers of adenosine 5'-O-(2-thiotriphosphate).己糖激酶和丙酮酸激酶反应中腺苷5'-O-(2-硫代三磷酸)的二价阳离子依赖性立体特异性。腺苷5'-O-(2-硫代三磷酸)非对映异构体的绝对立体化学。
J Biol Chem. 1978 Jul 25;253(14):4823-5.