Brown C M, Burnstock G
Br J Pharmacol. 1981 Jul;73(3):617-24. doi: 10.1111/j.1476-5381.1981.tb16796.x.
1 The relaxations induced by adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate (AMP) and adenosine on the carbachol-contracted taenia coli of the guinea-pig have been studied. ATP and ADP produce similar responses which differ in nature and time course from those of AMP and adenosine. 2 Theophylline, at concentrations (25-200 muM) lower than those which produce significant phosphodiesterase inhibition, blocks the effects of AMP and adenosine but fails to antagonize the responses elicited by ATP and ADP. The antagonism of adenosine by theophylline appears to be competitive. 3 Apamin (1-100 nM) blocks the inhibitory effects of ATP and ADP but fails to antagonize the responses to AMP and adenosine. The antagonism by apamin is non-competitive. 4 The results indicate that ATP and adenosine relax the taenia coli by activating different receptors and are consistent with the P1, P2 purinoceptor hypothesis.
1 研究了三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、一磷酸腺苷（AMP）和腺苷对豚鼠卡巴胆碱收缩的结肠带所引起的舒张作用。ATP和ADP产生相似的反应，其性质和时程与AMP和腺苷的反应不同。2 茶碱在低于产生显著磷酸二酯酶抑制作用的浓度（25 - 200 μM）时，阻断AMP和腺苷的作用，但不能拮抗ATP和ADP引起的反应。茶碱对腺苷的拮抗作用似乎是竞争性的。3 蜂毒明肽（1 - 100 nM）阻断ATP和ADP的抑制作用，但不能拮抗对AMP和腺苷的反应。蜂毒明肽的拮抗作用是非竞争性的。4 结果表明，ATP和腺苷通过激活不同的受体使结肠带舒张，这与P1、P2嘌呤受体假说一致。
