Paisey R, Jeans W D, Hartog M
Br J Radiol. 1984 Jul;57(679):561-4. doi: 10.1259/0007-1285-57-679-561.
Twenty-six acromegalics had measurements of serum growth hormone (GH) levels during a glucose tolerance test, X rays of the heel for heel pad thickness, and of the hand for bone/soft tissue ratio. These measurements were performed before and between 2 and 7 years after treatment, which was by transethmoidal hypophysectomy, external irradiation or a combination of the two. Neither the heel pad thickness nor bone/soft tissue ratio correlated with the mean serum GH nor with each other before and after treatment. The nine patients who were assessed as showing a good clinical response to treatment showed a significantly greater fall in mean serum GH than the 17 patients who were assessed as unchanged or partial responders (40.1 +/- 20 mmu/l compared with 9.9 +/- 14.0 mmu/l, p = 0.02). However, there were no significant differences in changes of heel pad thickness nor bone/soft tissue ratio between these groups. It is concluded that these radiological measurements of soft tissues are unhelpful in the follow-up of acromegalic patients.
26例肢端肥大症患者在葡萄糖耐量试验期间测定了血清生长激素（GH）水平，拍摄了足跟X线片以测量足跟垫厚度，并拍摄了手部X线片以测量骨/软组织比例。这些测量在经筛窦垂体切除术、外照射或两者联合治疗前以及治疗后2至7年期间进行。治疗前后，足跟垫厚度和骨/软组织比例与平均血清GH均无相关性，且二者之间也无相关性。被评估为对治疗有良好临床反应的9例患者，其平均血清GH下降幅度显著大于被评估为病情未改变或部分缓解的17例患者（分别为40.1±20 mU/L和9.9±14.0 mU/L，p = 0.02）。然而，这些组之间足跟垫厚度和骨/软组织比例的变化并无显著差异。结论是，这些软组织的放射学测量对肢端肥大症患者的随访并无帮助。
