MacSweeney J E, Baxter M A, Joplin G F
Department of Diagnostic Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Clin Radiol. 1990 Nov;42(5):348-50. doi: 10.1016/s0009-9260(05)82151-8.
The value of serial measurements of heel pad thickness as a clinical predictor of biochemical remission in acromegaly was assessed in 25 patients followed for up to 20 years after treatment by interstitial irradiation using yttrium-90 implantation. Growth hormone (GH) levels fell to 50% of baseline values within 12 months of therapy (P less than 0.001) and to 21% at 5 years, reaching normal levels after 10 years, constituting a biochemical cure maintained to the end of the study period. By contrast, heel pad thickness remained relatively stable, falling to 95% of baseline after 5 years (P less than 0.05) and to 87% after 20 years. There was no overall correlation between the measured parameters (r = 0.033, P greater than 0.05) suggesting that heel pad thickness is a poor predictor of biochemical remission in acromegaly.
对25例采用钇-90植入间质照射治疗的患者进行了长达20年的随访，评估了足跟垫厚度的系列测量值作为肢端肥大症生化缓解临床预测指标的价值。治疗后12个月内生长激素（GH）水平降至基线值的50%（P<0.001），5年时降至21%，10年后达到正常水平，构成了直至研究期末维持的生化治愈。相比之下，足跟垫厚度保持相对稳定，5年后降至基线的95%（P<0.05），20年后降至87%。测量参数之间无总体相关性（r=0.033，P>0.05），提示足跟垫厚度是肢端肥大症生化缓解的不良预测指标。
