Pastel R H, Fernstrom J D
Brain Res. 1984 May 23;300(2):243-55. doi: 10.1016/0006-8993(84)90835-7.
Clonidine was studied for its effects in rats on the occurrence of several EEG waves that characterize the sleep/waking cycle. Intraperitoneal administration of the drug (0.001-1.0 mg/kg) at the onset of the daily light period induced low frequency (4-7 Hz) rhythmical slow activity (RSA), and suppressed delta-wave occurrence. These effects were more prominent with increasing dose. Clonidine also had a biphasic effect on spindles: at low doses it suppressed, while at high doses it enhanced spindle occurrence. These effects could not be characterized as modifications in any of the classical sleep stages. A clearly non-classical state was induced by the clonidine in these studies. These results suggest that in rat, effects of clonidine cannot simply be interpreted as an alteration in one or more of the classically-defined sleep states.
研究了可乐定对大鼠几种表征睡眠/觉醒周期的脑电波出现情况的影响。在每日光照期开始时腹腔注射该药物（0.001 - 1.0毫克/千克）会诱发低频（4 - 7赫兹）节律性慢活动（RSA），并抑制δ波的出现。随着剂量增加，这些作用更加显著。可乐定对纺锤波也有双相作用：低剂量时抑制，高剂量时增强纺锤波的出现。这些作用不能被描述为对任何经典睡眠阶段的改变。在这些研究中，可乐定诱导出了一种明显的非经典状态。这些结果表明，在大鼠中，可乐定的作用不能简单地解释为对一种或多种经典定义的睡眠状态的改变。
