Block M, Gilbert E, Davis C
Cancer. 1984 Aug 1;54(3):590-5. doi: 10.1002/1097-0142(19840801)54:3<590::aid-cncr2820540334>3.0.co;2-3.
A case of neuroblastoma arising in an immature teratoma of the ovary in a 22-year-old woman is reported. Differentiation was grade 3 in the primary and metastases. Metastases to retroperitoneal, mediastinal, and supraclavicular lymph nodes and to bone were diagnosed 2 years after presentation of the primary tumor. Electron microscopic study demonstrated dense-core granules of the neurosecretory elements. Treatment with combination chemotherapy followed by radiotherapy resulted in complete remission which continues to the time of this report, more than 4 years after diagnosis of the primary tumor. Prolonged survival of metastasizing grade 3 immature teratoma is distinctly uncommon. The literature pertaining to this unusual tumor and to neuroblastoma of adults is reviewed.
报告了一例22岁女性卵巢未成熟畸胎瘤中发生神经母细胞瘤的病例。原发肿瘤及转移灶的分化程度均为3级。在原发肿瘤出现2年后，诊断出有腹膜后、纵隔、锁骨上淋巴结及骨转移。电子显微镜研究显示了神经分泌元件的致密核心颗粒。联合化疗后放疗的治疗导致完全缓解，自原发肿瘤诊断后已持续超过4年，至本报告撰写时仍处于缓解状态。转移性3级未成熟畸胎瘤的长期存活明显罕见。本文回顾了有关这种不寻常肿瘤及成人神经母细胞瘤的文献。
