金刚烷胺与血浆蛋白的体外结合
In vitro binding of amantadine to plasma proteins.
作者信息
Liu P, Cheng P J, Ing T S, Daugirdas J T, Jeevanandhan R, Soung L S, Galinis S
出版信息
Clin Neuropharmacol. 1984;7(2):149-51. doi: 10.1097/00002826-198406000-00005.
Abstract
In vitro binding of amantadine to plasma protein was assessed by ultrafiltration of plasma samples (from a blood bank) to which amantadine hydrochloride had been added. Approximately two-thirds of the amantadine was found to be protein-bound. The degree of protein binding was constant over a plasma amantadine concentration range of 100-2,000 ng/ml.
摘要
通过对添加了盐酸金刚烷胺的血浆样本（来自血库）进行超滤，评估金刚烷胺在体外与血浆蛋白的结合情况。发现约三分之二的金刚烷胺与蛋白结合。在血浆金刚烷胺浓度范围为100 - 2000纳克/毫升时，蛋白结合程度保持恒定。
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