Milligan T P, Morris H C, Hammond P M, Price C P
Department of Clinical Biochemistry, London Hospital Medical College, UK.
Ann Clin Biochem. 1994 Sep;31 ( Pt 5):492-6. doi: 10.1177/000456329403100512.
There is a limited amount of data on the binding of paracetamol to plasma proteins. It has been suggested that binding might influence the ability of some analytical methods to quantify the total amount of drug present in the plasma fraction--the basis of clinical experience in risk assessment and antidote usage. We have investigated the binding of paracetamol to plasma proteins using an ultrafiltration technique. In overdose and spiked uraemic plasma samples the mean percentage of paracetamol bound was 24.1 (1SD = 7.0) with no significant correlation with drug levels or degree of uraemia. There is a small but significant increase in binding with increasing serum albumin concentration both in plasma (rs = 0.549, P = 0.014) and in pure serum albumin solutions (rs = 0.848, P < 0.001).
关于对乙酰氨基酚与血浆蛋白结合的数据有限。有人认为，这种结合可能会影响某些分析方法定量血浆部分中药物总量的能力，而这正是风险评估和解毒剂使用临床经验的基础。我们使用超滤技术研究了对乙酰氨基酚与血浆蛋白的结合情况。在过量用药和加标的尿毒症血浆样本中，结合的对乙酰氨基酚的平均百分比为24.1（1标准差=7.0），与药物水平或尿毒症程度无显著相关性。在血浆（rs = 0.549，P = 0.014）和纯血清白蛋白溶液（rs = 0.848，P < 0.001）中，随着血清白蛋白浓度的增加，结合率有小幅但显著的升高。
