Rzasa P J, Caride V J, Prokop E K
Clin Chem. 1984 Jul;30(7):1240-3.
Discordant results for concentrations of choriogonadotropin (HCG) in sera from five of 162 women are reported, as determined with four commercial radioassay kits: Becton-Dickinson, Clinetics, Corning, and Hybritech. Results ranged from 11.2 to 36.7 int. units/L, when assayed with the Becton-Dickinson kit, but HCG was not detectable when assayed with the other kits. None of the patients was pregnant, and none had evidence of persistent trophoblastic or nontrophoblastic disease. Concentrations of lutropin, follitropin, thyrotropin, triglycerides, cholesterol, protein, and albumin were normal. Assay of diluted sera did not parallel the standard curve, and nonspecific binding in the patients' samples was negligible. Some kits for HCG may be influenced by inherent methodological factors or interfering serum constituents, which can lead to spurious results.
据报道，使用四种商业放射免疫分析试剂盒（Becton-Dickinson、Clinetics、Corning和Hybritech）对162名女性血清中的绒毛膜促性腺激素（HCG）浓度进行检测时，有5名女性的检测结果不一致。使用Becton-Dickinson试剂盒检测时，结果范围为11.2至36.7国际单位/升，但使用其他试剂盒检测时未检测到HCG。所有患者均未怀孕，也没有持续性滋养层或非滋养层疾病的证据。促黄体生成素、促卵泡生成素、促甲状腺激素、甘油三酯、胆固醇、蛋白质和白蛋白的浓度均正常。稀释血清的检测结果与标准曲线不平行，患者样本中的非特异性结合可忽略不计。一些HCG检测试剂盒可能会受到内在方法学因素或干扰血清成分的影响，从而导致假结果。
