Clark C V, Pentland B, Ewing D J, Clarke B F
Diabetes Care. 1984 May-Jun;7(3):224-7. doi: 10.2337/diacare.7.3.224.
Skin wrinkling, which may be dependent on peripheral autonomic innervation, was assessed in 100 normal and 42 diabetic subjects using a temperature-controlled water bath with immersion of the hands for 30 min. Markedly decreased skin wrinkling was observed in diabetic subjects and in manual workers, but did not correlate with cardiovascular tests of autonomic function, control, type or duration of diabetes, or diabetic complications. The cause of decreased skin wrinkling in people with diabetes is unexplained.
通过使用温度可控的水浴，将手浸入其中30分钟，对100名正常受试者和42名糖尿病受试者的皮肤起皱情况进行了评估，皮肤起皱可能依赖于外周自主神经支配。在糖尿病受试者和体力劳动者中观察到皮肤起皱明显减少，但与自主神经功能的心血管测试、糖尿病的控制情况、类型、病程或糖尿病并发症均无关联。糖尿病患者皮肤起皱减少的原因尚不清楚。
