Emanuelsson H, Hjalmarson A, Holmberg S, Waagstein F
Eur J Clin Pharmacol. 1985;28(5):489-93. doi: 10.1007/BF00544056.
The haemodynamic effects of felodipine 0.1 mg/kg p.o., a new arteriolar dilator, were studied in 7 patients with severe congestive heart failure of NYHA Class IV (Group A) and in 3 patients in Class II-III (Group B). In Group A, measurements were made before and 1 and 4 h after felodipine administration. There was a substantial fall in systemic arterial pressure, which was not associated with a compensatory tachycardia. In fact, there was a fall in heart rate from 92 to 82 beats/min 1 h after drug administration. The pulmonary capillary wedge pressure was reduced from 22 to 14 mm Hg and the cardiac index and stroke volume index rose significantly. Consequently, there was a marked reduction in systemic vascular resistance. In Group B measurements were performed at rest and during exercise before and 1 h after felodipine. The pulmonary wedge capillary pressure during exercise was lower than in the control situation. Coronary sinus flow was increased and there was a pronounced fall in coronary vascular resistance. The results would suggest that felodipine, by virtue of its ventricular unloading potency, might be a valuable drug in the treatment of congestive heart failure.
对7例纽约心脏协会（NYHA）IV级重度充血性心力衰竭患者（A组）和3例II - III级患者（B组）研究了新型小动脉扩张剂非洛地平0.1mg/kg口服后的血流动力学效应。在A组，于服用非洛地平前以及服药后1小时和4小时进行测量。体循环动脉压显著下降，且未伴有代偿性心动过速。实际上，给药1小时后心率从92次/分钟降至82次/分钟。肺毛细血管楔压从22mmHg降至14mmHg，心脏指数和每搏量指数显著升高。因此，体循环血管阻力明显降低。在B组，于休息时、运动期间以及服用非洛地平前和服药后1小时进行测量。运动期间的肺楔毛细血管压低于对照情况。冠状窦血流量增加，冠状血管阻力显著下降。结果表明，非洛地平凭借其减轻心室负荷的效能，可能是治疗充血性心力衰竭的一种有价值的药物。
