Neumann P, Schicha H, Tebbe U, Kreuzer H, Emrich D
Eur J Nucl Med. 1984;9(5):205-8. doi: 10.1007/BF00448540.
Multiple gated blood pool (MUGA) and contrast ventriculographic studies were performed within 24 h in 80 patients, 20 with 120 normokinetic wall segments and 60 with wall motion abnormalities in 239 of 360 wall segments. Three methods of evaluation of the radionuclide ventriculograms were compared with the results of the biplane contrast ventriculography which served as a standard: (1) qualitative analysis of the cine mode, (2) analysis of parametric scans (amplitude and phase images) and the phase histogram obtained by Fourier analysis, (3) quantitative determination of regional ejection fraction. Normal values were obtained from 20 patients with normal wall motion in the contrast angiogram. The overall sensitivity for the detection of wall motion abnormalities of high degree was 96% for method 1, 95% for method 2, and 90% for method 3, for those of low degree 72% for method 1, 63% for method 2, and 75% for method 3. Combining methods 2 and 3 the sensitivity was increased to 99% for high grade and to 81% for low grade wall motion abnormalities. The two methods showed a complementary effect because of different sensitivities in dependence of the localization of the wall motion abnormality. Although a high efficiency for the evaluation of left ventricular function was provided by the qualitative analysis of the cine mode the combination of Fourier analysis and the determination of regional ejection fraction should be preferred. It increases the sensitivity for the detection of wall motion abnormalities. Moreover, it offers quantitative data which improve the reproducibility and decrease the observer variability.
对80例患者在24小时内进行了多门控心血池（MUGA）和造影心室造影研究，其中20例患者的120个室壁节段运动正常，60例患者的360个室壁节段中有239个存在室壁运动异常。将三种评估放射性核素心室造影的方法与作为标准的双平面造影心室造影结果进行了比较：（1）电影模式的定性分析；（2）参数扫描（幅度和相位图像）及通过傅里叶分析获得的相位直方图分析；（3）局部射血分数的定量测定。正常数值来自造影血管造影中室壁运动正常的20例患者。对于高度室壁运动异常的检测，方法1的总体敏感性为96%，方法2为95%，方法3为90%；对于低度室壁运动异常，方法1为72%，方法2为63%，方法3为75%。将方法2和方法3结合，对于高度室壁运动异常，敏感性提高到99%，对于低度室壁运动异常提高到81%。由于对室壁运动异常定位的依赖性不同，这两种方法显示出互补效应。尽管电影模式的定性分析对评估左心室功能有较高效率，但应优先选择傅里叶分析和局部射血分数测定的组合。它提高了检测室壁运动异常的敏感性。此外，它提供了定量数据，提高了可重复性并减少了观察者的变异性。
