Sukamoto T, Yamamoto T, Watanabe S, Ueki S
Eur J Pharmacol. 1984 Apr 20;100(2):173-9. doi: 10.1016/0014-2999(84)90219-x.
Serotonin (5-HT, 1-10 micrograms), injected into the lateral ventricle of the urethanized, and conscious normotensive and spontaneously hypertensive rats produced a dose-dependent increase in blood pressure. In conscious rats, there was mainly a decrease in heart rate while variable changes in heart rate were elicited by intraventricular (i.c.v.) administration of 5-HT in anesthetized animals. These pressor responses and bradycardia caused by 5-HT in conscious rats were reduced by pretreatment with i.c.v. methysergide (25 micrograms). Microinjection of 5-HT (2.5-5 micrograms) directly into the medial hypothalamus and the anterior hypothalamus/preoptic area of conscious normotensive rats caused a pressor response accompanied by variable changes in heart rate. The present results indicate that urethane can affect the HR response to 5-HT injected i.c.v. without having a marked influence on the pressor response. These findings, which show that 5-HT produced a rise in BP independent of the anesthetized or conscious state and of normotension or hypertension, further confirm the idea that 5-HT plays a pressor role in the central regulation of the cardiovascular system.
将血清素（5-羟色胺，1-10微克）注入经氨基甲酸乙酯麻醉的、清醒的正常血压和自发性高血压大鼠的侧脑室后，血压呈剂量依赖性升高。在清醒大鼠中，主要是心率下降，而在麻醉动物中，脑室内（i.c.v.）注射5-羟色胺会引起心率的变化不定。清醒大鼠中由5-羟色胺引起的这些升压反应和心动过缓，可通过脑室内注射麦角新碱（25微克）预处理而减轻。将5-羟色胺（2.5-5微克）直接微量注射到清醒正常血压大鼠的内侧下丘脑和下丘脑前部/视前区，会引起升压反应并伴有心率的变化不定。目前的结果表明，氨基甲酸乙酯可影响对脑室内注射5-羟色胺的心率反应，而对升压反应无明显影响。这些结果表明，5-羟色胺可使血压升高，且与麻醉或清醒状态以及正常血压或高血压无关，进一步证实了5-羟色胺在心血管系统的中枢调节中起升压作用这一观点。
