Turmel A, De Montigny C
Eur J Pharmacol. 1984 Mar 23;99(2-3):241-4. doi: 10.1016/0014-2999(84)90247-4.
Adinazolam , a triazolobenzodiazepine , has been reported to be an effective antidepressant treatment in major depression. In the present study, a 14-day (but not a five-day) treatment with adinazolam enhanced the responsiveness of rat hippocampal pyramidal neurons to microiontophoretically applied 5-HT but not to NE. A 14-day treatment with diazepam failed to induce sensitization to either 5-HT or NE. Acute intravenous administration of adinazolam did not modify dorsal raphe 5-HT neuron firing rate. It is proposed that the antidepressant activity of adinazolam might be mediated by a heightened 5-HT neurotransmission.
阿地唑仑是一种三唑并苯二氮䓬类药物，据报道它在重度抑郁症中是一种有效的抗抑郁治疗药物。在本研究中，阿地唑仑进行14天（而非5天）的治疗可增强大鼠海马锥体神经元对微量离子导入5-羟色胺（5-HT）的反应性，但对去甲肾上腺素（NE）无此作用。地西泮进行14天的治疗未能诱导对5-HT或NE的敏感性。急性静脉注射阿地唑仑不会改变中缝背核5-HT神经元的放电频率。有人提出，阿地唑仑的抗抑郁活性可能是由增强的5-HT神经传递介导的。
