Sheveleva G A, Kiriushchenkov A P, Sheina N I, Silant'eva I V
Farmakol Toksikol. 1984 May-Jun;47(3):78-83.
Experiments on Wistar rats were made to study the effects of nicotine administered in doses of 0.4, 1.5, and 5 mg/kg (1/70, 1/20 and 1/5 of the LD50) on the functional state of the mother's body and embryogenesis under exposure throughout the entire pregnancy. The mother demonstrated abnormalities of nervous and cardiovascular functions, which were dose-dependent. Nicotine was shown to have an adverse effect on the formation of the cardiovascular system in embryos and ossification in the bone skeleton. The cardiovascular system tended towards an "organ to organ" injury within the mother-embryo system.
对Wistar大鼠进行实验，以研究在整个孕期给予0.4、1.5和5毫克/千克剂量（分别为LD50的1/70、1/20和1/5）的尼古丁对母体功能状态和胚胎发育的影响。母体表现出神经和心血管功能异常，且呈剂量依赖性。结果表明，尼古丁对胚胎心血管系统的形成和骨骼系统的骨化有不良影响。在母胎系统中，心血管系统倾向于“器官对器官”的损伤。
