Tebenchuk G M, Lukashuk V D, Lipkan G N, Stepanenko V V
Farmakol Toksikol. 1984 May-Jun;47(3):87-90.
Antitoxic properties of cobamamide, a coenzymic form of vitamin B12, were studied in experimental toxic hepatitis induced by CCl4. The data obtained as a result of the assessment of the bromosulfalene test and activity of sorbitol dehydrogenase and alanine aminotransferase point to a demonstrable hepatoprotective action of cobamamide. Normalization of the indicators studied evidences that the drug intensifies the recovery processes occurring in the liver of rabbits with toxic hepatitis.
研究了维生素B12的辅酶形式钴胺酰胺在四氯化碳诱导的实验性中毒性肝炎中的抗毒特性。通过对溴磺酚酞试验以及山梨醇脱氢酶和丙氨酸转氨酶活性的评估所获得的数据表明，钴胺酰胺具有明显的肝保护作用。所研究指标的正常化证明，该药物可加速中毒性肝炎家兔肝脏的恢复进程。
