Vigorita M G, Previtera T, Saporito G, Costa De Pasquale R, Circosta C, Occhiuto F
Farmaco Sci. 1984 May;39(5):403-13.
The analogy with the anti-inflammatory trifluoromethane-sulfonanilides prompted us to the synthesis of a series of trifluoroacetanilides which were found to maintain the pharmacological properties of the analog sulfonanilides. Many of the obtained compounds inhibited either the carrageenin-induced rat paw edema and the adjuvant-induced arthritis; some showed better anti-inflammatory properties than indomethacin and phenylbutazone. Acute toxicity and ulcerogenic effects were significantly lower than those of reference drugs.
与抗炎性三氟甲烷磺酰苯胺的类比促使我们合成了一系列三氟乙酰苯胺，发现它们保留了类似磺酰苯胺的药理特性。许多所得化合物抑制角叉菜胶诱导的大鼠足爪水肿和佐剂诱导的关节炎；有些表现出比吲哚美辛和保泰松更好的抗炎特性。急性毒性和致溃疡作用明显低于参比药物。
