Roberts A P, Story C J, Ryall R G
Diabetologia. 1984 May;26(5):389-91. doi: 10.1007/BF00266043.
Increased erythrocyte 2,3-bisphosphoglycerate concentrations are associated with increased haemoglobin glycosylation in patients with Type 1 diabetes mellitus who have no cause or symptoms of hypoxic stress. This change in 2,3-bisphosphoglycerate metabolism is additional to its response to changes in circulating haemoglobin concentration. Statistical analysis of data showed that erythrocyte 2,3-bisphosphoglycerate concentration did not correlate with the absolute concentration of circulating haemoglobin A1c, but with the proportion of haemoglobin glycosylated. This finding is consistent with the hypothesis that it is changes in the position of the erythrocyte oxygen dissociation curve which modulate the increase in 2,3-bisphosphoglycerate synthesis upon haemoglobin A1c formation.
在没有低氧应激原因或症状的1型糖尿病患者中，红细胞2,3-二磷酸甘油酸浓度升高与血红蛋白糖基化增加有关。2,3-二磷酸甘油酸代谢的这种变化是除了其对循环血红蛋白浓度变化的反应之外的。数据统计分析表明，红细胞2,3-二磷酸甘油酸浓度与循环糖化血红蛋白A1c的绝对浓度无关，而是与糖化血红蛋白的比例有关。这一发现与以下假设一致，即红细胞氧解离曲线位置的变化调节了糖化血红蛋白A1c形成时2,3-二磷酸甘油酸合成的增加。
