Christensen C W, Fujimoto J M
Gen Pharmacol. 1984;15(3):263-6. doi: 10.1016/0306-3623(84)90172-1.
The i.p. injection of Cd in mice will produce a dose related hypothermic response. The Cd appears to make the animals poikilothermic and their body temperature will approach the ambient temperature at which they are housed. The cause for this hypothermic action of Cd is not known, but we have demonstrated in our experiments that the effect may be partially related to a direct effect within the brain. In addition, the repeated injection of a low Cd dose (0.62 mg/kg) i.p. once daily for 3 days results in a profound tolerance to the Cd. A high dose (1.25 mg/kg i.p. once daily X 3 days) of Cd did not result in a similar tolerance phenomenon and a single injection of the high Cd dose 120 hr prior to the repeated low Cd dose regimen resulted in an obtunded tolerance response to the low dose. We propose that the higher Cd dose may have damaged the blood-brain barrier and this could account for the results we have observed.
给小鼠腹腔注射镉会产生与剂量相关的体温过低反应。镉似乎使动物变成变温动物，其体温会接近饲养它们的环境温度。镉这种体温过低作用的原因尚不清楚，但我们在实验中已证明，这种效应可能部分与大脑内的直接作用有关。此外，每天腹腔注射一次低剂量镉（0.62毫克/千克），连续注射3天，会导致对镉产生显著耐受性。高剂量镉（每天腹腔注射1.25毫克/千克，共3天）不会产生类似的耐受现象，并且在重复低剂量镉给药方案前120小时单次注射高剂量镉会导致对低剂量镉的耐受反应减弱。我们推测，较高剂量的镉可能破坏了血脑屏障，这可以解释我们所观察到的结果。
