Graziani G, Cantaluppi A, Casati S, Citterio A, Ponticelli C, Trifirò A, Borghi L, Sani E, Simoni I, Montanari A
Int J Artif Organs. 1984 Mar;7(2):85-8.
Plasma and skeletal muscle free amino acids were measured in patients submitted to Hemodialysis (HD) or Continuous Ambulatory Peritoneal Dialysis (CAPD) in order to evaluate the effects of these different dialysis modalities on amino acid pools; the data were compared with those obtained in control subjects and in patients with advanced Chronic Renal Failure (CRF) not submitted to Regular Dialysis Treatment (RDT). Our findings show low intracellular concentrations of VAL, total Branched Chain Amino Acid (BCAA) and TYR in uremic patients treated with CAPD but not in those undergoing HD. The observed differences in muscle amino acid pattern could be well explained by a changed amino acid metabolism regulation in CAPD, possibly related to the sustained hyperinsulinism and to an increased rate of hepatic protein synthesis.
对接受血液透析（HD）或持续性非卧床腹膜透析（CAPD）的患者测定血浆和骨骼肌游离氨基酸，以评估这些不同透析方式对氨基酸库的影响；将数据与在对照受试者以及未接受常规透析治疗（RDT）的晚期慢性肾衰竭（CRF）患者中获得的数据进行比较。我们的研究结果显示，接受CAPD治疗的尿毒症患者细胞内缬氨酸（VAL）、总支链氨基酸（BCAA）和酪氨酸（TYR）浓度较低，但接受HD治疗的患者并非如此。观察到的肌肉氨基酸模式差异可以很好地用CAPD中氨基酸代谢调节的改变来解释，这可能与持续的高胰岛素血症和肝脏蛋白质合成速率增加有关。
