Shoji T, Nishizawa Y, Nishitani H, Yamakawa M, Morii H
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Clin Nephrol. 1992 Nov;38(5):271-6.
We measured serum lipoprotein(a) [Lp (a)] concentrations in 50 uremic patients treated on continuous ambulatory peritoneal dialysis (CAPD) and compared them with those in 29 uremic patients on hemodialysis (HD) and those in 62 normal controls. The median values were 47.9 mg/dl in CAPD patients, 25.2 mg/dl in HD patients, and 11.7 mg/dl in controls, respectively. These differences were statistically significant when assessed by Kruskal-Wallis test (p < 0.0001). Thirty-five out of 50 patients on CAPD (70%) and 12 out of 29 patients on HD (41%) had Lp(a) concentrations above 30 mg/dl, whereas these high values were observed in only 15% of normal controls. This difference in prevalence of high Lp(a) was also significant by 2 x 3 chi-square test (p < 0.01). There was a significant positive correlation between Lp(a) and apolipoprotein B (r = 0.517, p < 0.0001). In CAPD patients, 9 with ischemic heart disease had a significantly higher median Lp(a) than those without it (67.4 vs 40.9 mg/dl, p < 0.01 by Mann-Whitney U-test). These results suggest that high levels of serum Lp(a) might contribute to an increased risk for ischemic heart disease in CAPD patients, and that there may be a relationship between Lp(a) and apolipoprotein B metabolism in CAPD patients.
我们检测了50例接受持续性非卧床腹膜透析（CAPD）治疗的尿毒症患者的血清脂蛋白(a)[Lp(a)]浓度，并将其与29例接受血液透析（HD）的尿毒症患者以及62例正常对照者的血清脂蛋白(a)浓度进行比较。CAPD患者的中位数为47.9mg/dl，HD患者为25.2mg/dl，对照组为11.7mg/dl。经Kruskal-Wallis检验评估，这些差异具有统计学意义（p<0.0001）。50例CAPD患者中有35例（70%）、29例HD患者中有12例（41%）的Lp(a)浓度高于30mg/dl，而正常对照者中只有15%出现这些高值。高Lp(a)患病率的这种差异经2×3卡方检验也具有统计学意义（p<0.01）。Lp(a)与载脂蛋白B之间存在显著正相关（r=0.517，p<0.0001）。在CAPD患者中，9例患有缺血性心脏病的患者的Lp(a)中位数显著高于未患缺血性心脏病的患者（67.4对40.9mg/dl，经Mann-Whitney U检验，p<0.01）。这些结果表明，血清Lp(a)水平升高可能会增加CAPD患者患缺血性心脏病的风险，并且CAPD患者中Lp(a)与载脂蛋白B代谢之间可能存在关联。
