Metivier B, Servin A, Renault H, Jacquot C
Int J Nucl Med Biol. 1984;11(1):103-5. doi: 10.1016/0047-0740(84)90043-3.
Simultaneous oral administration of digoxin and three benzamides (Metoclopramide, Alizapride, Bromopride) to the rat, modify digoxin's pharmacokinetic parameters: peak plasma concentration, elimination phase half life and bioavailability (Bromopride, Alizapride in function with dose-level). Our conclusion, is that drug-monitoring is necessary for this drug association.
对大鼠同时口服地高辛和三种苯甲酰胺类药物（胃复安、阿立必利、溴必利），会改变地高辛的药代动力学参数：血浆峰浓度、消除相半衰期和生物利用度（溴必利、阿立必利的生物利用度随剂量水平而变化）。我们的结论是，对于这种药物组合进行药物监测是必要的。
