肉碱和乙酰肉碱异构体对线粒体呼吸的影响。

Effects of carnitine and acetylcarnitine isomers on mitochondrial respiration.

作者信息

Farinella Z, Fiumara A, Bianciardi P, Guarcello V, Rizza V

出版信息

Int J Tissue React. 1984;6(2):141-3.

Abstract

Mitochondrial respiration was studied in the presence of carnitine or acetyl-carnitine isomers. The results demonstrate that 15 mM L-acetylcarnitine stimulates oxygen consumption by approximately 25%. D-acetylcarnitine (15 mM) had a slight inhibitory effect whereas racemic DL-acetylcarnitine (15 mM) markedly inhibited mitochondrial respiration. Similarly racemic DL-carnitine showed approximately 60% inhibition of mitochondrial respiration. L-carnitine or D-carnitine showed no significant effect on oxygen consumption. Further studies will be required to establish whether the carnitine or acetylcarnitine isomers competitively inhibit the acylcarnitine translocase systems of the mitochondrial membrane.

摘要

在肉碱或乙酰肉碱异构体存在的情况下研究了线粒体呼吸。结果表明，15 mM的L-乙酰肉碱可使耗氧量增加约25%。D-乙酰肉碱（15 mM）有轻微抑制作用，而外消旋DL-乙酰肉碱（15 mM）则显著抑制线粒体呼吸。同样，外消旋DL-肉碱对线粒体呼吸的抑制率约为60%。L-肉碱或D-肉碱对耗氧量无显著影响。需要进一步研究以确定肉碱或乙酰肉碱异构体是否竞争性抑制线粒体膜的酰基肉碱转位酶系统。