O'Day D M, Ray W A, Head W S, Robinson R D
Invest Ophthalmol Vis Sci. 1984 Jul;25(7):851-4.
Quantitative mycologic techniques were used to evaluate the efficacy of topical amphotericin B methyl ester in two models of yeast infection in rabbit eyes. Doses of 1%, 0.5%, and 0.15% were used in a model of superficial Candida albicans infection. The 1% dose of drug was highly efficacious, abolishing the disease after 2 days of treatment. With doses of 0.5% and 0.15%, decreasing efficacy was observed. Antifungal activity did not deteriorate when 1% prednisolone acetate was administered concomitantly with the 1% dose. In a model of deep stromal infection, the administration of topical 1% amphotericin B methyl ester was highly efficacious when the corneal epithelium was absent. Even in corneas with intact epithelium, a reduced though still significant effect was noted.
采用定量真菌学技术评估局部应用两性霉素B甲酯对兔眼两种酵母感染模型的疗效。在白色念珠菌浅表感染模型中使用了1%、0.5%和0.15%的剂量。1%剂量的药物疗效显著，治疗2天后疾病消失。使用0.5%和0.15%剂量时，疗效逐渐降低。当1%醋酸泼尼松龙与1%剂量的两性霉素B甲酯同时给药时，抗真菌活性并未降低。在深层基质感染模型中，当角膜上皮缺失时，局部应用1%两性霉素B甲酯具有高度疗效。即使在角膜上皮完整的情况下，也观察到了虽有所降低但仍显著的效果。
