Efficacy of antifungal agents in the cornea. I. A comparative study.

A standardized model of Candida albicans keratitis was developed in pigmented rabbits using a quantitative mycologic technique to evaluate the disease at intervals throughout the course. In this model, using two different infecting strains, the efficacy of five antifungal agents was compared. Amphotericin B, in concentrations of 0.5% to 0.075%, was superior to all other agents tested. Natamycin 5% ranked next, followed by 1% flucytosine, and 1% miconazole. Ketoconazole 1% was ineffective.