De Boeck C, Van Reempts P, Rigatto H, Chernick V
J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun;56(6):1507-11. doi: 10.1152/jappl.1984.56.6.1507.
The mechanism responsible for the decrease in ventilation during breathing of low fractional concentration of inspired O2 in the newborn infant is poorly understood. The present study tested the hypothesis that endogenous opiates account for this ventilatory decrease. Eleven healthy newborn infants breathed 15% O2, balance N2 for 5 min following an injection of saline and following an injection of naloxone. Neither injection caused a change in minute ventilation (VE) or ventilatory pattern when the infants were breathing room air. However, the decreased ventilation during hypoxia following naloxone was significantly less than that following saline. VE dropped about 14% following saline but only about 4% following naloxone. However, the adult ventilatory response to hypoxemia, i.e., a relatively sustained increase in VE, was not attained. Naloxone had no influence on the occurrence of periodic breathing during hypoxemia. Thus in the healthy full-term newborn infant, endogenous opiates account only for a part of the decreased ventilation during hypoxemia.
新生儿吸入低分数浓度氧气呼吸时通气量减少的机制目前还知之甚少。本研究检验了内源性阿片类物质导致这种通气量减少的假说。11名健康新生儿在注射生理盐水和注射纳洛酮后，吸入15%氧气、其余为氮气，持续5分钟。当婴儿呼吸室内空气时，两种注射均未引起分钟通气量（VE）或通气模式的改变。然而，纳洛酮注射后缺氧时通气量的减少明显少于生理盐水注射后。生理盐水注射后VE下降约14%，而纳洛酮注射后仅下降约4%。然而，未出现成人对低氧血症的通气反应，即VE相对持续增加。纳洛酮对低氧血症期间周期性呼吸的发生没有影响。因此，在健康足月儿中，内源性阿片类物质仅导致低氧血症期间通气量减少的一部分。
