Santiago T V, Sheft S A, Khan A U, Edelman N H
Am Rev Respir Dis. 1984 Aug;130(2):183-6. doi: 10.1164/arrd.1984.130.2.183.
Ventilatory and airway occlusion pressure responses to hypoxia were measured in 7 subjects with chronic obstructive pulmonary disease (COPD). Paired responses were obtained after the administration of saline or naloxone and, on separate days, in 5 of the 7 subjects, after 2 saline injections. Naloxone increased (p less than 0.05) the mean inspiratory flow and the ventilatory and airway occlusion pressure responses to hypoxia when compared with the saline responses. Resting ventilation and tidal volume also increased, but not significantly. Involvement of endogenously generated opioid substances in the control of breathing of patients with COPD is further suggested by this study.
对7名慢性阻塞性肺疾病（COPD）患者测量了对低氧的通气和气道阻塞压反应。在给予生理盐水或纳洛酮后获得配对反应，并且在不同日期，7名患者中的5名在两次注射生理盐水后进行测量。与生理盐水反应相比，纳洛酮增加了（p<0.05）平均吸气流量以及对低氧的通气和气道阻塞压反应。静息通气和潮气量也增加，但不显著。这项研究进一步表明内源性阿片类物质参与了COPD患者呼吸的控制。
